Penn Medicine is the University of Pennsylvania Health System (UPHS) plus the Perelman School of Medicine. It is an $11.9 billion enterprise powered by nearly 49,000 faculty and staff, operating six hospitals (Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Chester County Hospital, Lancaster General Health, Princeton Health, and Pennsylvania Hospital — the first hospital in the United States, chartered in 1751) plus Penn Medicine at Home, Good Shepherd Penn Partners Rehabilitation, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health. The Perelman School of Medicine was awarded $580 million in NIH funding in fiscal year 2023.
From an API perspective, Penn Medicine runs a production Epic-backed HL7 FHIR R4 endpoint at https://ssproxy.pennhealth.com/PRD-FHIR/api/FHIR/R4 (Epic Organization ID 346, implementation description "University of Pennsylvania Health Systems FHIR Server"). The CapabilityStatement instantiates us-core-server|6.1.0 and the HL7 Bulk Data Access IG, exposes 59 FHIR resource types covering Patient Access (clinical + claims) and Provider Directory per CMS-9115-F, and protects them with OAuth 2.0 / SMART-on-FHIR. Penn Medicine also operates the MyPennMedicine MyChart patient portal and the PhysicianLink referring-provider portal, and publishes open-source informatics work through several Perelman School of Medicine GitHub orgs (Penn-Medicine-CHCI, pennsignals, PMACS, pennbiobank).
APIs.json: https://github.com/api-evangelist/penn-medicine
- Healthcare
- Hospital
- Academic Medical Center
- FHIR
- SMART On FHIR
- Patient Access
- Provider Directory
- CMS Interoperability
- US Core
- Bulk Data
- Epic
- Created: 2026-05-23
- Modified: 2026-05-23
The University of Pennsylvania Health Systems FHIR Server. Epic (November 2025) on the back end, conforming to US Core 6.1.0 and the HL7 Bulk Data Access IG. Serves Patient Access (clinical + claims) and Provider Directory data per CMS-9115-F, exposing 59 FHIR resource types including Patient, AllergyIntolerance, Condition, Observation, MedicationRequest, Immunization, Procedure, Encounter, DiagnosticReport, DocumentReference, Coverage, ExplanationOfBenefit, Claim, Practitioner, PractitionerRole, Organization, Location, and Endpoint. App registration is performed through Epic on FHIR (https://fhir.epic.com) by selecting Penn Medicine (Organization ID 346) as the target.
- Human URL: https://www.pennmedicine.org/for-health-care-professionals/for-physicians/electronic-medical-records
- Base URL:
https://ssproxy.pennhealth.com/PRD-FHIR/api/FHIR/R4
- FHIR
- SMART On FHIR
- Patient Access
- Provider Directory
- Bulk Data
- US Core
- Documentation
- API Reference
- OpenAPI — OpenAPI Specification
- Postman Collection — Postman Collection 2.1
- Open Collection — Open Collection 1.0
- JSON Schema — JSON Schema
- JSON Schema — JSON Schema
- JSON Schema — JSON Schema
- JSON Schema — JSON Schema
- Example
- Example
- Example
- Example
- Example
- Authentication
- Sandbox
MyChart-based patient portal that gives Penn Medicine patients access to medical records, lab results, secure messaging with their care team, telehealth visits, medication refills, prescription management, bill pay, and appointment scheduling across UPHS facilities. SMART apps approved via Epic on FHIR connect to the underlying Penn Medicine FHIR R4 API.
- Human URL: https://www.pennmedicine.org/patient-resources/mypennmedicine
- Base URL:
https://secure.mypennmedicine.org
- Patient Portal
- MyChart
- Patient Access
- Portal
- Documentation
- Postman Collection — Postman Collection 2.1
- Open Collection — Open Collection 1.0
EpicLink-based portal for community and referring physicians that provides secure access to Penn Medicine patient records: clinical notes, lab and imaging results, medication lists, and the ability to refer patients and follow care for shared patients.
- Human URL: https://www.pennmedicine.org/for-health-care-professionals/for-physicians/electronic-medical-records/physicianlink
- Base URL:
https://secure3.pennmedicine.org/EpicLink
- Referring Provider
- EMR Access
- Epic
- Portal
- Documentation
- Postman Collection — Postman Collection 2.1
- Open Collection — Open Collection 1.0
Penn Medicine and the Perelman School of Medicine publish open-source health-informatics software across several GitHub organizations: Penn Medicine Center for Health Care Innovation (Penn-Medicine-CHCI, behind the Cobalt mental-health platform — cobalt-api in Java and cobalt-web in TypeScript); Penn Signals / Penn Medicine Predictive Healthcare (pennsignals — Databricks MCP agent templates; historically the home of CHIME, the COVID-19 Hospital Impact Model); Penn Medicine Academic Computing Services (PMACS — 17 Rails libraries, JSON:API tools, Oracle adapters, and Slate API docs); and the Penn Medicine BioBank (pennbiobank).
- Human URL: https://github.com/pennmedicine
- Open Source
- Health Informatics
- GitHub
- GitHub Organization
- GitHub Organization
- GitHub Organization
- GitHub Organization
- GitHub Organization
- GitHub Repository
- GitHub Repository
- Postman Collection — Postman Collection 2.1
- Open Collection — Open Collection 1.0
- Portal
- Developer Portal
- GitHub Organization
- GitHub Organization
- GitHub Organization
- Blog
- Privacy Policy
- Terms of Service
- Compliance
- Support
- Spectral Rules
- JSON-LD — JSON-LD
- Vocabulary
- Plans
- Rate Limits
- Fin Ops
- Features
- Use Cases
- Integrations
- Solutions
FN: Kin Lane Email: info@apievangelist.com