Target identification is a critical first step in Computer-Aided Drug Design (CADD), where the goal is to determine the biological molecules—typically proteins—that play a key role in a disease process. By identifying and validating these targets, researchers can focus drug discovery efforts more effectively, increasing the chances of developing successful therapeutics.Open Targets is a collaborative platform that integrates data from genomics, transcriptomics, clinical studies, and other sources to help researchers systematically identify and prioritize potential drug targets. It provides a robust, data-driven framework to explore the association between targets and diseases, making it a valuable resource for early-stage drug discovery.
Investigate a Ensembl gene ID (ENSG00000134086) for gene or Experimental Factor Ontology(EFO_0000349) for diseases.
python -m opentarget --help
Usage: python -m opentarget <ID> <request_type>
Examples:
python -m opentarget EFO_0005952 target_disease_evidence
python -m opentarget EFO_0000349 associated_targets
python -m opentarget ENSG00000134086 associated_diseases
Valid request types and their descriptions:
associated_targets: Find targets associated with a specific disease or phenotype
associated_diseases: Find diseases and phenotypes associated with a specific target
target_disease_evidence: Explore evidence that supports a specific target-disease association
