diff --git a/connection_instrumented.go b/connection_instrumented.go
index 92a2dda9..a6504d6e 100644
--- a/connection_instrumented.go
+++ b/connection_instrumented.go
@@ -3,9 +3,8 @@ package pop
 import (
 	"database/sql"
 	"database/sql/driver"
+	"context"
 	"fmt"
-	"slices"
-	"sync"
 
 	"github.com/jmoiron/sqlx"
 	"github.com/luna-duclos/instrumentedsql"
@@ -16,12 +15,8 @@ import (
 	"github.com/gobuffalo/pop/v6/logging"
 )
 
-const instrumentedDriverName = "instrumented-sql-driver"
-
-var sqlDriverLock = sync.Mutex{}
-
-func instrumentDriver(deets *ConnectionDetails, defaultDriverName string) (driverName, dialect string, err error) {
-	driverName = defaultDriverName
+func instrumentDriver(deets *ConnectionDetails, defaultDriverName string) (drv driver.Driver, dialect string, err error) {
+	driverName := defaultDriverName
 	if deets.Driver != "" {
 		driverName = deets.Driver
 	}
@@ -35,8 +30,8 @@ func instrumentDriver(deets *ConnectionDetails, defaultDriverName string) (drive
 			)
 		}
 
-		// If instrumentation is disabled, we just return the driver name we got (e.g. "pgx").
-		return driverName, dialect, nil
+		// If instrumentation is disabled, return nil driver to signal non-instrumented path.
+		return nil, dialect, nil
 	}
 
 	if len(deets.InstrumentedDriverOptions) == 0 {
@@ -46,41 +41,23 @@ func instrumentDriver(deets *ConnectionDetails, defaultDriverName string) (drive
 		)
 	}
 
-	var dr driver.Driver
-	var newDriverName string
 	switch CanonicalDialect(driverName) {
 	case nameCockroach:
 		fallthrough
 	case namePostgreSQL:
-		dr = new(pgx.Driver)
-		newDriverName = instrumentedDriverName + "-" + namePostgreSQL
+		drv = new(pgx.Driver)
 	case nameMariaDB:
 		fallthrough
 	case nameMySQL:
-		dr = mysqld.MySQLDriver{}
-		newDriverName = instrumentedDriverName + "-" + nameMySQL
+		drv = mysqld.MySQLDriver{}
 	case nameSQLite3:
-		var err error
-		dr, err = newSQLiteDriver()
+		drv, err = newSQLiteDriver()
 		if err != nil {
-			return "", "", err
+			return nil, "", err
 		}
-		newDriverName = instrumentedDriverName + "-" + nameSQLite3
-	}
-
-	sqlDriverLock.Lock()
-	defer sqlDriverLock.Unlock()
-
-	var found bool
-	if slices.Contains(sql.Drivers(), newDriverName) {
-		found = true
-	}
-
-	if !found {
-		sql.Register(newDriverName, instrumentedsql.WrapDriver(dr, deets.InstrumentedDriverOptions...))
 	}
 
-	return newDriverName, dialect, nil
+	return instrumentedsql.WrapDriver(drv, deets.InstrumentedDriverOptions...), dialect, nil
 }
 
 // openPotentiallyInstrumentedConnection first opens a raw SQL connection and then wraps it with `sqlx`.
@@ -90,15 +67,37 @@ func instrumentDriver(deets *ConnectionDetails, defaultDriverName string) (drive
 // a custom driver name when using instrumentation, this detection would fail
 // otherwise.
 func openPotentiallyInstrumentedConnection(c dialect, dsn string) (*sqlx.DB, error) {
-	driverName, dialect, err := instrumentDriver(c.Details(), c.DefaultDriver())
+	drv, dialect, err := instrumentDriver(c.Details(), c.DefaultDriver())
 	if err != nil {
 		return nil, err
 	}
 
-	con, err := sql.Open(driverName, dsn)
-	if err != nil {
-		return nil, fmt.Errorf("could not open database connection: %w", err)
+	var con *sql.DB
+	if drv != nil {
+		// Use sql.OpenDB with the per-connection wrapped driver instead of
+		// sql.Register + sql.Open, which only registers one driver per driver type
+		// regardless of per-connection options.
+		con = sql.OpenDB(&driverConnector{drv, dsn})
+	} else {
+		con, err = sql.Open(c.DefaultDriver(), dsn)
+		if err != nil {
+			return nil, fmt.Errorf("could not open database connection: %w", err)
+		}
 	}
 
 	return sqlx.NewDb(con, dialect), nil
 }
+
+// driverConnector wraps a driver.Driver with a DSN to implement driver.Connector.
+type driverConnector struct {
+	driver driver.Driver
+	dsn    string
+}
+
+func (dc *driverConnector) Connect(ctx context.Context) (driver.Conn, error) {
+	return dc.driver.Open(dc.dsn)
+}
+
+func (dc *driverConnector) Driver() driver.Driver {
+	return dc.driver
+}